Paolo De Coppi | International and Private Care

Paolo De Coppi is the Nuffield Chair of Paediatric Surgery, the NIHR Professor of Paediatric Surgery, and Consultant Paediatric Surgeon at the Great Ormond Street Hospital for Children and Regenerative Medicine Section, Developmental Biology & Cancer Programme at the UCL GOS Institute of Child Health, London, UK. Paolo De Coppi is also an Honorary Professor at the Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, US; and at the Division Woman and Child, University Hospitals KU Leuven, Leuven, Belgium.

He has a special interest in research and treatments using minimally invasive techniques. His research has led to many ground-breaking new treatments for children. Professor de Coppi has a special interest in congenital malformation and their treatment using minimally invasive techniques. He has focused his research interests on stem cells and tissue engineering, trying to find new modalities for the treatment of complex congenital anomalies. While working at the Childrens’ Hospital in Boston-US, he had the opportunity of identifying a new source of cells for therapeutic applications showing the possibility of using stem cells from amniotic fluid. This finding generated an international patent and garnered the cover story of Nature Biotechnology in January 2007. He has received funding for exploring the possibility of using these cells for the treatment of congenital malformations. He has more recently focused on developing reliable methods for stem cell isolation, expansion and differentiation at a clinical level (GMP-grade). Finally, in 2010 he was part of the team that performed the first successful transplantation of a tissue-engineered trachea on a child at the Great Ormond Street Hospital.

He has published more than 240 peer-reviewed articles in journals such as The Lancet, Nature Biotechnology, PNAS; supervised more than 40 research fellow and Ph.D. students; and has been awarded various national and international grants in excess of £23 million. He is on the editorial boards of the Journal of Pediatric Surgery, Pediatric Surgery International, and Fetal and Maternal Medicine Review.

Neonatal and paediatric surgery
Keyhole surgery
Oesophageal atresia
Diaphragmatic hernia, inguinal and umbilical hernia
Gastroesophageal reflux
Gastrostomy and fundoplication
Appendicectomy
Constipation
Anorectal malformation
Undescended testes
Tissue engineering and major reconstructions

Neonatal and paediatric general surgery
Prenatal diagnosis and counselling
Keyhole surgery

Training:

MD from the University of Padua, Italy
MR from the University of Padua, Italy
PhD from the University of Padua, Italy 
Since 2013: Honorary Associate Professor, Division Woman and Child, University Hospitals KU Leuven, Leuven, Belgium
Since 2009: Adjunct Assistant Professor (Hon.), Wake Forest Institute for Regenerative Medicine, NC, US
Since 2006: Honorary Consultant Paediatric Surgery at Great Ormond Street Hospital, London, UK
Since 2005: Honorary Assistant Professor Paediatric Surgery, University of Padua, Italy
NIHR Professor of Paediatric Surgery and Consultant Paediatric Surgeon at the Great Ormond Street Hospital for Children 
Head of Stem Cells & Regenerative Medicine Section, Developmental Biology & Cancer Programme at the UCL Institute of Child Health, London, UK

Membership:

Member of British Association of Paediatric Surgeons and the European Paediatric Surgeons Association

Professor de Coppi has a special interest in congenital malformation and their treatment using minimally invasive techniques. He has focused his research interests on stem cells and tissue engineering, trying to find new modalities for the treatment of complex congenital anomalies. While working at the Childrens’ Hospital in Boston-US, he had the opportunity of identifying a new source of cells for therapeutic applications showing the possibility of using stem cells from amniotic fluid. This finding generated an international patent and garnered the cover story of Nature Biotechnology January 2007. He has received funding for exploring the possibility of using these cells for the treatment of congenital malformations. He has more recently focused on developing reliable methods for stem cell isolation, expansion and differentiation at a clinical level (GMP-grade). Finally, in 2010 he was part of the team that performed the first successful transplantation of a tissue-engineered trachea on a child at the Great Ormond Street Hospital.

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A revolution in body building – regenerative medicine Bringing Research to Life seminar

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Publications & articles

Di Trapani, M., Bassi, G., Fontana, E., Giacomello, L., Pozzobon, M., Guillot, P. V., . . . Krampera, M. 2015. Immune regulatory properties of CD117(pos) amniotic fluid stem cells vary according to gestational age. Stem Cells Dev. 24 (1) pp 132-143.

Shaw, S. W., Blundell, M. P., Pipino, C., Shangaris, P., Maghsoudlou, P., Ramachandra, D. L., . . . de Coppi, P. 2015. Sheep CD34+ amniotic fluid cells have hematopoietic potential and engraft after autologous in utero transplantation. Stem Cells. 33 (1) pp. 122-132.

Fishman, J. M., Wiles, K., Lowdell, M. W., De Coppi, P., Elliott, M. J., Atala, A., & Birchall, M. A. 2014. Airway tissue engineering: an update. Expert Opin Biol Ther. 14 (10) pp. 1477-1491.

Zani, A., Cananzi, M., Fascetti-Leon, F., Lauriti, G., Smith, V. V., Bollini, S., . . . De Coppi, P. 2014. Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism. Gut. 63 (2) pp. 300-309.

Morigi, M., & De Coppi, P. 2014. Cell therapy for kidney injury: different options and mechanisms--mesenchymal and amniotic fluid stem cells. Nephron Exp Nephrol. 126 (2) pp. 59-?.

Shangaris, P., Loukogeorgakis, S. P., Blundell, M. P., Petra, E., Ramachandra, D., Maghsoudlou, P., . . . David, A. L. 2014. Congenic Amniotic Fluid Stem Cells Show Stable Long-Term Engraftment in the Haematopoietic System after In Utero Transplantation. REPRODUCTIVE SCIENCES. 21 (3), p.83A.

Archacka, K., Pozzobon, M., Repele, A., De Coppi, P., Campanella, M., & Rossi, C. A. 2014. Culturing muscle fibres in hanging drop: A novel approach to solve an old problem. Biology of the Cell. 106 (2) pp. 72-82.

Archacka, K., Pozzobon, M., Repele, A., Rossi, C. A., Campanella, M., & De Coppi, P. 2014. Culturing muscle fibres in hanging drop: a novel approach to solve an old problem. Biol Cell. 106 (2) pp. 72-82.

Arnaud, A. P., Rex, D., Elliott, M. J., Curry, J., Kiely, E., Pierro, A., . . . De Coppi, P. 2014. Early Experience of Thoracoscopic Aortopexy for Severe Tracheomalacia in Infants After Esophageal Atresia and Tracheo-esophageal Fistula Repair. JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES. 24 (7) pp. 508-512.

De Coppi, P. 2014. Engineering tissue for the fetus: Stem cells and matrix signalling. Biochemical Society Transactions. 42 (3) pp. 631-635.