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Dr Catriona Duncan

Consultant in Paediatric Oncology and Lead for Retinoblastoma Service
Dr Catriona Duncan

Overview

As the lead for the retinoblastoma service at GOSH, Dr Duncan works closely with NHS England and Children’s Hospital Birmingham to review and audit the retinoblastoma service across the two UK centres.  

As well as a Consultant in Paediatric Oncology, Dr Duncan is an educational supervisor and clinical supervisor of both senior and junior trainees and is the Oncology representative responsible for improving quality and flow of delivery of service to families at GOSH.  

Credentials

  • Retinoblastoma

Education: 

  • BSc Basic Medical Sciences with Anatomy; King’s College School of Medicine and Dentistry, University of London. Research Project – Developmental Anatomy “Retinoic Acid and Homeobox Genes” 
  • MBBS
  • Fellow in Paediatric Oncology
  • Fellow at Sydney Children’s Hospital 
  • MRCP

Membership: 

  • Member of SIOP Renal tumour special interest group
  • Member of SIOPEN 
  • Member of CHECT (Childhood eye cancer trust) scientific committee 
  • Member of CCLG renal tumor group, neuroblastoma, retinoblastoma group 
  • Member of SIOP
  • Member of Eurorb group

BSc Research Project: The Role of Homeobox Genes and Retinoic Acid in the development of the chick hindbrain 

During this project, Dr Duncan identified the presence of specific homeobox gene via immunolocalisation for a transient period during the development of chick hindbrain. She then tested the hypothesis that retinoic acid may be acting locally as a switch on the identified homebox gene engrailed. Teratogenic effects were observed secondary to retinoic acid at sites of engrailed expression. 

Dr Duncan was responsible for doing all the lab work including microscopic dissection of the chick embryos, preparation for immunocytochemistry and interpretation of the results.

Research during the year as Glaxo Paediatric Respiratory Research Fellow 

Dr Duncan was responsible for the recruitment of children with asthma to a randomised double-blind, double-dummy 2-way crossover trial comparing the effects of fluticasone propionate nebules and prednisolone tablets on the hypothalamic-pituitary- adrenal axis in children with asthma. They were looking at the safety aspects. The results found that fluticasone propionate had a significantly smaller effect on HPA axis that prednisolone in doses used in the acute setting. As well as recruiting and consenting the children and their parents she visited them at home to record data and collect samples and they had my pager as an emergency contact.   

She was responsible for setting up a pilot study looking at using different concentrations of nebulised saline to induce sputum production in children whose asthma was stable at the time and non-asthmatic controls. This was to allow for the analysis of their sputum initially for inflammatory cells and then to measure leukotriene levels. 

News & Publications

Primary Intravenous Chemotherapy for Group D retinoblastoma: a 13-year retrospective analysis  

Fabian, Ido D ; Stacey, Andrew W ; Johnson, Kenneth P ; Onadim, Zerrin ; Chowdhury, Tanzina ; Duncan, Catriona ; Reddy, M Ashwin ; Sagoo, Mandeep S 

BMJ Publishing Group Ltd. 

British Journal of Ophthalmology, 13 December 2016 

Long-term Visual Acuty, Strabismus and Nystagmus Outcomes following multimodalitu treatment in group D Retinoblastoma eyes.  

Idi. D. Fabian, Zishan Naem, Andrew.w.Stacey, Tanzina Chowdhury, Catriona Duncan, M.Ashwin Reddy and Mandeep Sagoo  

J.AJO.2017.0.003 P137-143 

The management of retinoblastoma 

Fabian, Ido ; Onadim, Zerrin ; Karaa, Esin ; Duncan, Catriona ; Chowdhury, Tanzina ; Scheimberg, Irene ; Ohnuma, Shin-Ichi ; Reddy, M. ; Sagoo, Mandeep 

Oncogene, 2018, Vol.37(12), pp.1551-1560 

Variation in Toll-like receptor 9 gene modifies the risk of infection in children treated for acute lymphoblastic leukaemia 

Bhadri VA, Beckett SM, Duncan C, Marshall GM, Ashton LM 

Leuk Lymphoma 2012 Sep53(9) 828-30 

Does chemotherapy affect the visual outcome in children with optic pathway glioma? A systematic review of the evidence 

Moreno L, Bautista F, Ashley S, Duncan C, Zacharoulis S 

Eur J Cancer 2010 Aug 46 (12) 2253-9 

A Prospective Study of Admissions for Febrile Neutropenia in Secondary Paediatric (Shared Care) Units in South East England.  

C Duncan, JC Chisholm, S Freeman, U Riley, M Sharland, K Pritchard-Jones  

Paediatric Blood Cancer 49 2007, 678-681 

HPA-axis effects of nebulised fluticasone propionate compared with oral prednisolone in childhood asthma.  

Price J, Lenney W, Duncan C, Green L, Flood Y, Daley-Yates P, Barnacle H, Efthimiou J.  

Respir Med 2002 Aug; 96(8):625-31.

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