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Bone Marrow Transplant

Nurses preparing medicine on Butterfly Ward

Overview

The Bone Marrow Transplant (BMT) Unit is the largest paediatric BMT centre in the UK. We provide a comprehensive haematopoietic stem cell transplant service for children with life-threatening haematological, immunological, metabolic, rheumatological and gastroenterological conditions.

Only 20% of our patients have suitably matched family donors so many of our transplants are performed from volunteer adult bone marrow, peripheral blood stem cell or cord blood donations. The unit specialises in ‘reduced toxicity’ conditioning and in cellular therapies for treatment of viral complications post BMT. We are involved in cutting-edge research with the UCL Institute of Child Health focusing on gene therapy and immunotherapy.

Please be aware that private referrals for NHS eligible patients are not possible for this service. This is because children requiring a BMT will need continued and well-co-ordinated care, and good communication from the outset with their local paediatric services is essential. By entering the private treatment route, we are unable to provide the long term local support services required.

The department is JACIE accredited and is able to offer a second opinion service for clinicians from around the world. 

Watch our film about the BMT unit at GOSH.

Clinical outcomes

The BMT Unit runs a comprehensive stem cell transplant (SCT) service for children with life-threatening diseases. The BMT Unit is the largest paediatric BMT centre in the UK and now performs approximately 90 transplant procedures every year.

We measure our transplant outcomes in a range of ways including survival for all conditions treated, survival by groups of similar conditions, and complications of treatment.

Our overall patient survival for allograft transplant is 85%. Our overall patient survival for allograft transplant – malignancies only - is 79%. Malignancies have the lowest overall survival rate of all conditions treated by stem cell transplantation because children who have been pre-treated with a lot of chemotherapy, can experience more toxicity during SCT. Ongoing clinical research seeks to learn more about how to treat these conditions to improve survival rates.

For more informaiton about our clinical outcomes please click here.

Conditions we treat

  • Leukaemia
  • Solid tumours
  • Bone marrow failure
  • Immunodeficiency diseases
  • Inherited metabolic disorders
  • Autoimmune or immune dysregulatory diseases

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