Harry Leitch 医生
概述
Dr Harry Leitch is an Associate Professor and Honorary Consultant in Clinical Genetics and Genomic Medicine, based in the Genetics & Genomic Medicine Department at UCL Great Ormond Street Institute of Child Health and the North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Foundation Trust.
相关资质
Paediatric genetics
Rare disease genetics
Dysmorphology, birth defects, developmental delay, intellectual disability
Genetics of infertility
'Genetics and genomics
Rare disease diagnostics
Genomic medicine
N=1 therapy
Stem cell biology
Germ cell development
Reproductive biology
Epigenetics
Bachelor of Arts in Physiology, Development & Neuroscience, University of Cambridge
Master of Arts, University of Cambridge
PhD in Developmental & Stem Cell Biology, University of Cambridge
Bachelor of Medicine & Bachelor of Surgery, University of Cambridge
Member of the Royal College of Paediatrics and Child Health
Certificate in Medical Genetics, Royal College of Pathologists
Postgraduate Certificate in the Interpretation & Clinical Application of Genomic Data, University of London
Pluripotency, epigenetics, genetics, stem cell biology, reproduction, developmental biology, germline
development, developmental disorders and infertility.
https://profiles.ucl.ac.uk/88423-harry-leitch
新闻和论文发表
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2024 Sepulveda-Rincon LP, Wang YF, Whilding C, Ojarikre OA, Turner JMA, Leitch HG. Interrogating the potential of primordial germ cells by injection into early mouse embryos. Developmental Cell 59, 695-704.e5
2024 Shah P, Hill R, Dion C, Clark SJ, Abakir A, Willems J, Arends MJ, Garaycoechea JI, Leitch HG, Reik W, Crossan G. Primordial germ cell DNA demethylation and development require DNA translesion synthesis. Nature Communications 15, 3734
2022 Peshimam N, Farah H, Caswell R, Ellard S, Jan W, Calder AD, Cobben J, Kariholu U, Leitch HG. Sedaghatian spondylometaphyseal dysplasia
2021 Hamazaki N, Kyogoku H, Araki H, Miura F, Horikawa C, Hamada N, Shimamoto S, Hikabe O, Nakashima K, Kitajima T, Ito T, Leitch HG, Hayashi K. Reconstitution of the oocyte transcriptional network with transcription factors. Nature 286, 493-6.
2021 Posfai E, Lanner F, Mulas C, Leitch HG. All models are wrong, but some are useful: establishing standards for stem cell-based embryo models. Stem Cell Reports 16(5):1117-1141
2021 Ramakrishna NB, Murison K, Miska EA, Leitch HG. Epigenetic Regulation during Primordial Germ Cell Development and Differentiation. Sexual Development 15(5-6):411-431
2018 Hill PWS, Leitch HG*, Sun Z*, Requena-Torres C*, Amouroux R*, Trufero M, Borkowska M, Terragni J, Vaisvila R, Linnett S, Dharmalingham G, Haberle V, Lenhard B, Zheng Y, Pradhan S, Hajkova P. Epigenetic reprogramming enables the primordial
germ cell-to-gonocyte transition in mouse. Nature 555(7696), 392–396
2018 Zhang M*, Leitch HG*#, Tang WWC, Festuccia N, Hall-Ponsele E, Nichols J, Surani MA, Smith A, Chambers I#. Esrrb complementation rescues development of Nanog-null germ cells. Cell Reports 9;22(2), 332-9
2013 Leitch HG, Nichols J, Humphreys P, Mulas C, Martello G, Lee C, Jones K, Surani MA and Smith A. Rebuilding pluripotency from primordial germ cells. Stem Cell Reports 1(1), 66-78
2013 Leitch HG*, McEwen KR*, Turp A, Encheva V, Carroll T, Grabole N, Mansfield W, Nashun B, Knezovich JG, Smith A, Surani MA and Hajkova P. Naïve pluripotency is associated with global DNA hypomethylation. Nature Structural & Molecular Biology
20, 311–316
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