Hoong-Wei Gan 医生
概述
Dr Hoong-Wei Gan has been a consultant paediatric endocrinologist at Great Ormond Street Hospital for Children since 2019. He qualified in medicine at the University of Nottingham Medical School (2006), and subsequently completed his paediatric endocrinology subspecialty training in Nottingham and London (GOSH, University College London Hospital and the Royal London Hospital). He is Co-Chair of the British Society for Paediatric Endocrinology & Diabetes Special Interest Group in Hypothalamo-Pituitary Axis Tumours (HPAT) and coordinates the National HPAT Advisory Group. At GOSH, he helped set up the first collaborative, multidisciplinary long-term follow-up clinic for childhood brain tumour survivors, which has been featured in the Macmillan Cancer Support charity toolkit for developing cancer rehabilitation services.
He has a longstanding interest in the hormonal effects of brain tumours and their treatment, particularly on the hypothalamus and pituitary gland, having completed both his research degrees in the area at UCL Great Ormond Street Institute of Child Health. His MSc thesis (2013) examined long-term neuroendocrine outcomes in children with optic pathway gliomas followed up over 30 years at GOSH (the largest such study to date), whilst his PhD (2020) focussed on the quantification of appetite-regulating hormones in children with hypothalamic obesity (partially funded by the British Society for Paediatric Endocrinology & Diabetes and the NIHR GOSH Biomedical Research Centre). He remains research active in the area, having published the first evidence-based national guideline for the management of paediatric craniopharyngioma, and is also primary or sub investigator on a number of ongoing drug trials at GOSH.
He additionally has a particular interest in the education and training of future generations of paediatric endocrinologists, being Co-Lead for Education and Training in his NHS department, and Education Lead for Digital Learning with the GOSH Learning Academy
相关资质
General paediatric endocrinology
Disorders of growth and puberty
Congenital and acquired hypopituitarism
Hypothalamic obesity
Neuroendocrine effects of childhood cancer and their treatments, particularly brain tumours
Thyroid disorders
Adrenal disorders
Neuroendocrine effects of brain tumours and their treatments
Congenital and acquired hypothalamic and pituitary disorders
Hypothalamic obesity
2004 Bachelor of Medical Sciences BMedSci (1st class honours, Nottingham)
2006 Bachelor of Medicine, Bachelor of Surgery BMBS (Nottingham)
2010 Member of the Royal College of Paediatrics & Child Health MRCPCH
2013 Master of Science in Paediatrics & Child Health: Advanced Paediatrics MSc (Distinction, UCL)
2020 Doctor of Philosophy PhD (UCL)
Memberships:
Co-Chair, British Society for Paediatric Endocrinology & Diabetes Hypothalamo-Pituitary Axis Tumour (HPAT) Special Interest Group; Deputy Chair, UK National Craniopharyngioma Guideline Development Group; European Society for Paediatric Endocrinology (ESPE); International Society of Paediatric Endocrinology Europe (SIOP-E); SIOP-E Brain Tumour Group: Craniopharyngioma and Low-Grade Glioma Working Groups; International Late Effects of Childhood Cancer Guideline Harmonisation Group; British Society for Paediatric Endocrinology & Diabetes (BSPED); Children's Cancer & Leukaemia Group (CCLG); Royal College of Paediatrics & Child Health (RCPCH)
Long-term outcomes and endocrine management of survivors of paediatric brain tumours
Understanding the pathophysiology of and developing novel therapies for hypothalamic obesity
Endocrine effects of newer molecular therapies in neuro-oncology
新闻和论文发表
1. Otth M, Scheinemann K, Ajithkumar T, Aquilina K, Avula S, Gan HW, Janssens GO, Lemiere J, Morana G, Opocher E, Pfister SM, Porro G, Sahm F, Thomale UW, van Egmond-Ebbeling M, van Santen HM, Pizer B, Rutkowski S on behalf of the SIOPE Brain Tumour Group. Overview of European standard clinical practice recommendations for multidisciplinary teams involved in the treatment of central nervous system tumours in children and adolescents – SIOPE Brain Tumour Group. EJC Paediatr Oncol 2024; 3:100166 (doi 10.1016/j.ejcped.2024.100166).
2. Gan HW, Cerbone M, Dattani MT. Appetite- and weight-regulating neuroendocrine circuitry in hypothalamic obesity. Endocr Rev 2024; 45(3):309-342 (PMID 38019584; doi: 10.1210/endrev/bnad033).
3. Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques T, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA. National UK guidelines for the management of paediatric craniopharyngioma. Lancet Diab Endocrinol 2023; 11(9):694-706 (PMID 37549682; doi 10.1016/S2213-8587(23)00162-6).
4. Gan HW, Leeson C, Aitkenhead H, Dattani M. Inaccuracies in plasma oxytocin extraction and enzyme immunoassay techniques. Compr Psychoneuroendocinol 2023; 15:100188 (PMID 37360277; doi 10.1016/j.cpnec.2023.100188).
5. Mushtaq T, Ali SR, Boulos N, Boyle R, Cheetham T, Davies JH, Elder CJ, Gan HW, Hindmarsh PC, Katugampola H, Krones N, Salomon Estebanez MS, Shenoy S, Tollerfield S, Wong SC, Regan F Developed by the Paediatric Adrenal Insufficiency Group on behalf of the British Society for Paediatric Endocrinology and Diabetes (BSPED). Emergency and perioperative management of adrenal insufficiency in children and young people: British Society for Paediatric Endocrinology and Diabetes consensus guidance. Arch Dis Child 2023 (PMID 37045585, doi 10.1136/archdischild-2022-325156).
6. Walker DA, Aquilina K, Spoudeas H, Pilotto C, Gan HW, Meijer L. A new era for optic pathway glioma: a developmental brain tumor with life-long health consequences. Front Pediatr 2023; 11:1038937 (PMID 37033188, doi 10.3389/fped.2023.1038937).
7. Picariello S, Cerbone M, D’Arco F, Gan HW, O’Hare P, Aquilina K, Opocher E, Hargrave D, Spoudeas HA. A 40-year cohort study of evolving hypothalamic dysfunction in infants and young children (<3 years) with optic pathway gliomas. Cancers (Basel) 2022; 14(3):747 (PMID 35159015, doi 10.3390/cancers14030747).
8. Hage C, Gan HW, Ibba A, Patti G, Dattani M, Loche S, Maghnie M, Salvatori R. Advances in differential diagnosis and management of growth hormone deficiency in children. Nat Rev Endocrinol 2021; 17(10):608-624 (PMID 34417587, doi 10.1038/s41574-021-00539-5).
9. Gan HW, Phipps K, Aquilina K, Gaze MN, Hayward R, Spoudeas HA. Neuroendocrine morbidity after pediatric optic gliomas: a longitudinal analysis of 166 children over 30 years. J Clin Endocrinol Metab 2015; 100(10):3787-99 (PMID 26218754, doi 10.1210/jc.2015-2028).
10. Gan HW, Spoudeas HA. Long term follow up of survivors of childhood cancer (SIGN Clinical Guideline 132). Arch Dis Child Educ Pract Ed 2014; 99(4):138-43 (PMID 24639409, doi 10.1136/archdischild-2013-305452).
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