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Jack Bartram 医生

小儿血液科专家及顾问医师

概述

杰克.巴特拉姆医生分别在伦敦国王学院医院,哈默史密斯医院,圣玛丽医院以及大奥蒙德街儿童医院进行过血液病学的专业培训。他曾是伦敦大学学院大奥蒙德街儿童健康研究院的博士,之后在加拿大多伦多的病童医院(“SickKids”) 担任白血病研究项目的研究员。他的研究方向专注于前沿白血病诊断技术的使用。

杰克的临床兴趣在于小儿恶性及非恶性血液疾病。他是所在部门负责分子诊断的带头人。他非常积极地参与研究学习,以预测儿童血液恶性肿瘤的结果。

相关资质

  • 小儿恶性血液病
  • 急性淋巴细胞白血病
  • 白血病微小残留病
  • 分子诊断
  • 小儿非恶性血液病
  • 开发新的血液恶性肿瘤诊断方法
  • 白血病生物学​​
  • 内外科学士 MBChB (Hons)
  • 英国皇家儿科学院成员 (MRCPCH)
  • 英国皇家病理学院研究员 (FRCPath)
  • 开发新的血液恶性肿瘤诊断方法
  • 白血病微小残留病检测
  • 中枢神经系统白血病
  • 白血病生物学​​

新闻和论文发表

Bartram J, Goulden N, Wright G, Adams S, Brooks T, Edwards D, Inglott S, Yousafzai Y, Hubank M, Halsey C. (2017) High throughput sequencing in acute lymphoblastic leukaemia reveals clonal architecture of central nervous system and bone marrow compartments. Haematologica. doi: 10.3324/haematol.2017.174987

O'Connor D*, Enshaei A*, Bartram J*, Hancock J, Harrison C, Hough R, Samarasinghe S, Schwab C, Vora A, Wade R, Moppett J, Moorman A, and Goulden N. (2017) Genotype-specific MRD interpretation improves stratification in paediatric acute lymphoblastic leukaemia. Journal of Clinical Oncology. doi: 10.1200/JCO.2017.74.0049  [*co-first authors]

Walf-Vorderwülbecke V, Pearce K, Brooks T, Hubank M, van den Heuvel-Eibrink MM, Zwaan CM, Adams S, Edwards D, Bartram J, Samarasinghe S, Ancliff P, Khwaja A, Goulden N, Williams G, de Boer J, Williams O. (2017) Targeting acute myeloid leukaemia by drug-induced c-MYB degradation. Leukemia. doi: 10.1038/leu.2017.317.

O'Connor D, Moorman AV, Wade R, Hancock J, Tan RM, Bartram J, Moppett J, Schwab C, Patrick K, Harrison CJ, Hough R, Goulden N, Vora A, Samarasinghe S. (2016) Use of Minimal Residual Disease Assessment to Redefine Induction Failure in Pediatric Acute Lymphoblastic Leukemia. Journal of Clinical Oncology. 35(6):660-667. doi: 10.1200/JCO.2016.69.6278.

Bartram J, Mountjoy E, Brooks T, Hancock J, Williamson H, Wright G, Moppett J, Goulden N, Hubank M. (2016) Accurate sample assignment in a multiplexed, ultra-sensitive, high-throughput sequencing assay for minimal residual disease. Journal of Molecular Diagnostics. 18(4):494-506. doi: 10.1016/j.jmoldx.2016.02.008

Bashford-Rogers RJ, Nicolaou KA, Bartram J, Goulden NJ, Loizou L, Koumas L, Chi J, Hubank M, Kellam P, Costeas PA, Vassiliou GS. (2016) Eye on the B-ALL: B-cell receptor repertoires reveal persistence of numerous B-lymphoblastic leukemia subclones from diagnosis to relapse. Leukemia. 30(12):2312-2321. doi: 10.1038/leu.2016.142.

Bartram J, Wade R, Vora A, Hancock J, Mitchell C, Kinsey S, Steward C, Moppett J, Goulden N. (2016) Excellent outcome of minimal residual disease-defined low-risk patients is sustained with more than 10 years follow-up: results of UK paediatric acute lymphoblastic leukaemia trials 1997-2003. Archives of Disease in Childhood. 101(5):449-54. doi: 10.1136/archdischild-2015-309617.

Stepensky P, Bartram J, Barth TF, Lehmberg K, Walther P, Amann K, Philips AD, Beringer O, Zur Stadt U, Schulz A, Amrolia P, Weintraub M, Debatin KM, Hoenig M, Posovszky C. (2013) Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due to STXBP2/ MUNC18-2 mutations. Pediatric Blood and Cancer. 60(7):1215-22. doi: 10.1002/pbc.24475.

Moller HJ, Nielsen MJ, Bartram J, Dick MC, Height SE, Moestrup SK, Rees DC. (2011) Soluble CD163 levels in children with sickle cell disease. British Journal of Haematology. 153(1):105-10. doi: 10.1111/j.1365-2141.2011.08580.x.

Bartram JL, Thein SL, Gardner K, Egberongbe Y, D'Silva P, Height SE, Dick MC, O'Driscoll S, Rees DC. (2010) Outcome of children with sickle cell disease admitted to intensive care - a single institution experience. British Journal of Haematology. 150(5):614-7. doi: 10.1111/j.1365-2141.2010.08272.x.

Gardner K, Bell C, Bartram JL, Allman M, Awogbade M, Rees DC, Ervine M, Thein SL. (2010) Outcome of adults with sickle cell disease admitted to critical care – A single institution experience. British Journal of Haematology. 150(5):610-3. doi: 10.1111/j.1365-2141.2010.08271.x.

Bartram JL, O'Driscoll S, Kulasekararaj AG, Height SE, Dick M, Patel S, Rees DC. (2011) Portacaths are safe for long-term regular blood transfusion in children with sickle cell anaemia. Archives of Disease in Childhood. 96(11):1082-4. doi: 10.1136/ adc.2009.173856.

Deane CR, Goss D, Bartram J, Pohl KR, Height SE, Sibtain N, Jarosz J, Thein SL, Rees DC. (2010) Extracranial internal carotid arterial disease in children with sickle cell anemia. Haematologica. 95(8):1287-92. doi: 10.3324/haematol.2010.022624.

Rees DC, Lambert C, Cooper E, Bartram J, Goss D, Deane C, Thein SL. (2009) Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency is not associated with Cerebrovascular Disease in Children with Sickle Cell Anemia. Blood. 114(3):742-3. doi: 10.1182/blood-2009-04-216861.

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