زراعة الغدة الزعترية

Complete DiGeorge Syndrome

DiGeorge Syndrome is a primary immunodeficiency, often but not always, characterised by cellular (T-cell) deficiency, characteristic facies, congenital heart disease and hypocalcemia. DiGeorge Syndrome is caused by abnormal formation of certain tissues during foetal development. The incidence of DiGeorge Syndrome is about 1:4000 live births.

Complete DiGeorge Syndrome is used to describe the population of infants who, while having DiGeorge Syndrome, are also lacking a thymus. The anomaly occurs in less than 1% of children with DiGeorge Syndrome. Without a thymus, children suffering from Complete DiGeorge Syndrome have an extremely poor immune system and their life expectancy is typically less than 2 years old.

“The thymus gland is a ‘school’ for the immune system” Professor Davies explains, “through the thymus gland the immune system develops and is ‘taught’ how to recognise and attack invading germs but not the body’s own cells.” Children without a thymus gland do not have this 'school' to teach their immune system, and therefore have a very poor immune system.

Thymus transplant

A thymus transplant provides a treatment option for children suffering Complete DiGeorge Syndrome. A thymus transplant is a complex procedure that requires highly specialised laboratory facilities and experts. GOSH staff developed the programme by working with existing gene and cell therapy programmes that have been running for decades.The expertise of the Immunology team and the scientists at GOSH has allowed the hospital to offer this unique and life saving treatment for children around the world.

GOSH is one of only two centres in the world to offer Thymus transplants exclusively for children with Complete DiGeorge Syndrome.

The procedure involves cultivating donor thymus samples in a laboratory before transplanting them into the thigh of a child. Through the transplant a child's immune system slowly recovers after it is 'taught' by the implanted thymus.

Why GOSH?

Great Ormond Street Hospital for Children (GOSH) in London is an international centre of excellence in paediatric care, globally recognised as one of the few world-class hospitals for children suffering from rare, complex or multiple conditions. GOSH has been a pioneer in paediatrics ever since it admitted its first patients in 1852, and continues to be trusted as a global leader in the treatment of sick children.

GOSH is uniquely set up to treat and care for children with multiple and complex conditions. Specialising in only the most complex of conditions, GOSH has over 60 paediatric specialities under one roof, the largest of any NHS hospital in the UK. This allows GOSH to coordinate care within multidisciplinary teams which include multiple specialities and world-leading experts and each patient’s care is tailored to their unique health care needs.

GOSH places great emphasis on the support and care provided for children and families by nurturing an open and supportive atmosphere and providing services to cover all the families unique social and psychological needs. Children receive the highest standards of care and attention from the expert team of medical and support staff during their stay at GOSH, and are always treated with respect, trust, concern and openness.

إذا رغبت بإحالة طفلك للحصول على العلاج وليقوم البروفيسور ديفيز Davies وفريقه بفحصه ، فيرجى منك تعبئة النموذج الموجود أدناه. وسيتصل بك أحد أعضاء فريقنا خلال يومي عمل.