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Prof Waseem Qasim

Consultant in Immunology and Bone Marrow Transplants

Overview

Professor Waseem Qasim is a Consultant in Immunology who works closely with the Bone Marrow Transplant department. His area of expertise is children with inherited immune disorders and cell therapies used in transplant. This includes molecular diagnostics, in particular immunology and genetic testing for immunodeficiency. He works as part of multi-disciplinary team for the preparation and management of children before and after transplantation, aiming to provide the most appropriate and best quality treatments for children.

Languages Spoken:

  • English

Credentials

  • Inherited and genetic defects of the immune system
  • Transplant and transplant immunology
  • Cell and gene therapy; gene editing
  • Management of children with inherited immune disorders who require bone marrow transplantation
  • Severe combined immune deficiency (SCID) including RAG, ADA and SCID-X1. Combined immune deficiency (CID)
  • Bare lymphocyte syndrome (MHC class II deficiency)
  • Chronic granulomatous disease
  • Leucocyte adhesion deficiency
  • Wiskott Aldrich, IPEX and other conditions

Training:

  • B Med Sci (Hons) in Immunology from Newcastle University
  • MBBS from Newcastle University 
  • MRCP (UK)
  • MRCPCH (UK)
  • PhD Doctor of Philosophy – gene therapy from University College London

Membership:

  • Royal College of Paediatrics and Child Health
  • Royal College of Physicians
  • Cell and gene therapy
  • Retroviral and lentiviral vectors
  • Gene editing technology
  • Haematopoietic stem cell transplantation

News & Publications

Morfopoulou, S., Mee, ET., Connaughton, SM., Brown, JR., Gilmour, K., Chong, WK., Duprex, WP., Ferguson, D., Hubank, M., Hutchinson, C., Kaliakatsos, M., McQuaid, S., Paine, S., Plagnol, V., Ruis, C., Virasami, A., Zhan, H., Jacques, TS., Schepelmann, S., Qasim, W. 2017. Breuer J. Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis. Acta Neuropathol. 133(1) pp. 139 – 147.

Morfopoulou, S., Mee, ET., Connaughton, SM., Brown, JR., Gilmour, K., Chong, WK., Duprex, WP., Ferguson, D., Hubank, M., Hutchinson, C., Kaliakatsos, M., McQuaid, S., Paine, S., Plagnol, V., Ruis, C., Virasami, A., Zhan, H., Jacques, TS., Schepelmann, S., Qasim, W. 2017. Breuer J. Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis. Acta Neuropathol. 133(1) pp. 139 – 147.

Bacchelli, C., Moretti, FA., Carmo, M., Adams, S., Stanescu, HC., Pearce, K., Madkaikar, M., Gilmour, KC., Nicholas, AK., Woods, CG., Kleta, R., Beales, PL., Qasim, W., Gaspar, HB. 2017. Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency. J Allergy Clin Immunol. 139(2) pp. 634 – 642.

Morfopoulou, S., Brown, JR., Davies, EG., Anderson, G., Virasami, A., Qasim, W., Chong, WK., Hubank, M., Plagnol, V., Desforges, M., Jacques, TS., Talbot, PJ., Breuer, J. 2016. Human Coronavirus OC43 Associated with Fatal Encephalitis. N Engl J Med. 375(5) pp. 497 – 498.

Mock, U., Nickolay, L., Philip, B., Cheung, GW., Zhan, H., Johnston, IC., Kaiser, AD., Peggs, K., Pule, M., Thrasher, AJ., Qasim, W. 2016. Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS prodigy. Cytotherapy. 18(8) pp. 1002 – 1011.

Georgiadis, C., Syed, F., Petrova, A., Abdul-Wahab, A., Lwin, SM., Farzaneh, F., Chan, L., Ghani, S., Fleck, RA., Glover, L., McMillan, JR., Chen, M., Thrasher, AJ., McGrath, JA., Di, WL., Qasim, W.  2016. Lentiviral Engineered Fibroblasts Expressing Codon-Optimized COL7A1 Restore Anchoring Fibrils in RDEB. J Invest Dermatol. 136(1) pp. 284 - 292.

Hiwarkar, P., Qasim, W,. Ricciardelli, I., Gilmour, K., Quezada, S., Saudemont, A., Amrolia, P., Veys, P. 2015. Cord blood T cells mediate enhanced antitumor effects compared with adult peripheral blood T cells. Blood. 126(26) pp. 2882 – 2891.

Qasim, W., Brunetto, M., Gehring, AJ., Xue, SA., Schurich, A., Khakpoor, A., Zhan, H., Ciccorossi, P., Gilmour, K., Cavallone, D, Moriconi, F., Farzhenah, F., Mazzoni, A,. Chan, L., Morris, E., Thrasher, A., Maini, MK., Bonino, F., Stauss, H., Bertoletti, A. 2015. Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient. J Hepatol. 62(2) pp. 486 – 491.

Hassan, A., Lee, P., Maggina, P., Xu, JH., Moreira, D., Slatter, M., Nademi, Z., Worth, A.,Adams, S., Jones, A., Cale, C., Allwood, Z., Rao, K., Chiesa, R., Amrolia, P., Gaspar, H., Davies, EG., Veys, P., Gennery, A., Qasim, W. 2014. Host natural killer immunity is a key indicator of permissiveness for donor cell engraftment in patients with severe combined immunodeficiency. J Allergy Clin Immunol. 133(6) pp. 1660 – 1666.

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