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Dr Nikhil Thapar

Consultant and Senior Lecturer in Paediatric Gastroenterology

Overview

Dr Nikhil Thapar works within the Gastroenterology Unit at Great Ormond Street Hospital (GOSH). He is the Head of the Neurogastroenterology and Motility Unit at GOSH and Academic Lead for Gastroenterology for the combined Clinical Academic Unit across GOSH and UCL Great Ormond Street Institute of Child Health (ICH). 

Having completed training in general paediatrics and neonatology, Dr Thapar went on to specialise in paediatric gastroenterology and thereafter in paediatric neurogastroenterology and motility. Additionally, he completed a PhD in regenerative medicine of the gut nervous system and leads a research group at ICH with a focus on improving the understanding of the causes and development of disease, as well as the diagnosis and management of gut motility disorders including creating stem cell therapies.  

He is a recognised international expert in paediatric neurogastroenterology and gut motility. His area of expertise includes gastrointestinal (GI) motility and functional disorders ranging from the most common, such as gastro-oesophageal reflux, constipation and abdominal pain, through to the more severe conditions such as oesophageal achalasia and paediatric intestinal pseudo-obstruction. As a father himself, Dr Thapar’s ethos is to provide the best contemporary expertise with the utmost care, compassion and respect for the children he treats and their families 

Languages Spoken:

  • English
  • Hindi
  • Punjabi
  • Swahili (part fluent)

Credentials

  • Dysphagia / oesophageal motility disorders
  • Gastro-oesophageal reflux (disease)
  • Gastroparesis
  • Recurrent abdominal pain
  • Infantile colic
  • Intestinal pseudo-obstruction 
  • Hirschsprung’s disease
  • Constipation
  • General concerns about feeding, growth and development
  • Diarrhoea
  • Coeliac disease

• Allied disorders influencing gut motility and sensation including inflammatory conditions of the GI tract, immune dysfunction, endocrine disorders, allergy, metabolic, connective tissue and central nervous system disorders such as neurological impairment

Training:

  • Intercalated BSc in biomedical sciences (First class Hons) from the University of Southampton
  • Bachelor of Medicine with Distinction Honours from the University of Southampton
  • MRCP (UK)
  • FRCPCH (UK)
  • Postgraduate certificate in health research and development from the University of Portsmouth
  • Postgraduate paediatric training in the Wessex region and subspecialist training in paediatric gastroenterology in London
  • PhD from Queen Mary, University of London studying the therapeutic potential of stem cells for gut motility disorders 

Membership:

  • European Society of Paediatric Gastroenterology Hepatology and Nutrition (sits on council and chairs the gastroenterology committee)
  • Executive director of the Academy of Paediatric Gastroenterology (delivering education to families and healthcare professionals)
  • British Society of Paediatric Gastroenterology Hepatology and Nutrition (sat on council, founded and chaired its gut motility disorders working group)
  • British Society of Gastroenterology (sat on its research committee)
  • United European Gastroenterology (sat on its future trends committee)
  • Medicines for Children Research Network

Nikhil Thapar leads a research programme studying gut motility disorders and their treatment, with a particular focus on improving diagnosis, understanding the molecular and genetic mechanisms underlying such disorders as well as the developing novel therapies including stem cells and gut tissue engineering. The team have been responsible for improved diagnostics and have made significant progress in the understanding of normal and aberrant development of the enteric neuro-musculature, and the development of stem cell therapies for gut disease.

Insurers

Dr Nikhil Thapar is covered by the following insurers:

News & Publications

Nikhil Thapar has written over 100 peer-reviewed papers and book chapters. Dr Thapar is co-editor of ‘Paediatric Neurogastroenterology’ the only textbook available internationally on this area. 

Recent publications include:

Mutalib, M., Rawat, D., Lindley, K., Borrelli, O., Perring, S., Auth, MKH., Thapar, N. 2017. BSPGHAN Motility Working Group position statement: paediatric multichannel intraluminal pH impedance monitoring-indications, methods and interpretation. Frontline Gastroenterology. 8(3) pp.156-162. 

Di Nardo, G., Di Lorenzo, C., Lauro, A., Stanghellini, V., Thapar, N et al. 2017. Chronic intestinal pseudo-obstruction in children and adults: diagnosis and therapeutic options. Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society. 

Koppen, IJN., Broekaert, IJ., Wilschanski, M., Papadopoulou, A., Ribes-Koninckx, C., Thapar, N et al. 2017. The Role of Polyethylene Glycol in the Treatment of Functional Constipation in Children. Journal of Paediatric Gastroenterology and nutrition. 

Rybak, A., Pesce, M., Thapar, N., Borrelli, O. 2017. Gastro-Esophageal Reflux in Children. International journal of molecular sciences. 18(8).

Romano, C., van Wynckel, M., Hulst, J., Broekaert, I., Bronsky, J., Dall'Oglio, L., Mis, NF., Hojsak, I., Orel, R., Papadopoulou, A., Schaeppi, M., Thapar, N et al. 2017. European Society for Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for the Evaluation and Treatment of Gastrointestinal and Nutritional Complications in Children with Neurological Impairment. Journal of Paediatric Gastroenterology and nutrition. 65(2) pp. 242-264.

McCann, CJ., Cooper, JE., Natarajan, D., Jevans, B., Burnett, LE., Burns, AJ., Thapar, N. 2017. Transplantation of enteric nervous system stem cells rescues nitric oxide synthase deficient mouse colon. Nature Communications. 8. 

Tan, YW., Borrelli, O., Lindley, K., Thapar, N., Curry, J. 2017. Duhamel operation for children with distal colonic dysmotility. Pediatric Surgery International. 1-8. 

Saliakellis, E., Thapar, N., Roebuck, D., Cristofori, F., Cross, K., Kiely, E., Curry, J., Lindley, K., Borrelli, O. 2017. Long-term outcomes of Heller's myotomy and balloon dilatation in childhood achalasia. European Journal of Pediatrics. 176(7) pp. 899-907,

Perin, S., McCann, CJ., Borrelli, O., De Coppi, P., Thapar, N. 2017. Update on Foregut Molecular Embryology and Role of Regenerative Medicine Therapies. Frontiers in Pediatrics. 5.  

Borrelli, O., Pescarin, M., Saliakellis, E., Tambucci, R., Quitadamo, P., Valitutti, F., Rybak, A., Lindley, KJ., Thapar, N. 2016. Sequential incremental doses of bisacodyl increase the diagnostic accuracy of colonic manometry. Neurogastroenterology and Motility. 28(11) pp. 1747-1755.

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