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Dr Darren Hargrave

Consultant Paediatric Oncologist

Overview

Professor Darren Hargrave joined Great Ormond Street Hospital (GOSH) in 2011 having previously worked at The Royal Marsden Hospital in London. He was appointed in 2017 as the GOSH Children’s Charity Clinical Professor in Paediatric Neuro-oncology.

Prof Hargrave specialises in paediatric neuro-oncology (tumours of the brain and spine) and the development of new anti-cancer drugs for children and adolescents. He trained in the UK and Canada (Hospital for Sick Children, Toronto). He is an international leader in his field and the Chair (Elect) of the European SIOP-E Children’s Brain Tumour Group and a member of several national and international clinical and research committees.  He is a Chief Investigator of several completed, on-going and planned clinical trials in paediatric cancer, ranging from “first-in-child” to international randomised studies.

Early in my oncology career I was inspired to work with children with brain tumours and to develop better treatments and improve outcomes by understanding the biology of the tumours.

Credentials

  • Neuro-oncology (brain tumours)
  • Experimental therapies for childhood cancer 
  • Neurofibromatosis-related tumours
  • MB.ChB Hons University of Leeds
  • MD University of London
  • MRCP
  • FRCPCH
  • Trained in GOSH, the Royal Marsden Hospital and the Hospital for Sick Children in Toronto. 
  • Research degree with the Cancer Genome Project, Sanger Centre and Institute of Cancer Research
  • The biology of childhood brain tumours
  • The use of innovative imaging techniques in childhood cancer 
  • Drug development of targeted therapies in childhood and adolescent oncology

News & Publications

Stone, T.J., Keeley, A., Virasami, A., Harkness, W., Tisdall, M., Izquierdo Delgado, E., Gutteridge, A., Brooks, T., Kristiansen, M., Chalker, J., Wilkhu, L., Mifsud, W., Apps, J., Thom, M., Hubank, M., Forshew, T., Cross, J.H., Hargrave, D., Ham, J., Jacques, T.S. 2017. Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours. Acta Neuropathol. 

Jones, D.T.W., Kieran, M.W., Bouffet, E., Alexandrescu, S., Bandopadhayay, P., Bornhorst, M., Ellison, D., Fangusaro, J., Fisher, M.I., Foreman, N., Fouladi, M., Hargrave, D., Hawkins, C., Jabado, N., Massimino, M., Mueller, S., Perilongo, G., Schouten-van Meeteren, A.Y.N., Tabori, U., Warren, K., Waanders, A.J., Walker, D., Weiss, W., Witt, O., Wright, K., Zhu, Y., Bowers, D.C., Pfister, S.M., Packer, R.J. 2017. Pediatric Low-Grade Gliomas: Next Biologically Driven Steps. Neuro Oncol.

Kieran, M.W., Chisholm, J., Casanova, M., Brandes, A.A., Aerts, I., Bouffet, E., Bailey, S., Leary, S., MacDonald, T.J., Mechinaud, F., Cohen, K.J., Riccardi, R., Mason, W., Hargrave, D., Kalambakas, S., Deshpande, P., Tai, F., Hurh, E., Geoerger, B. 2017. Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma. Neuro Oncol. 

Byrne, S., Connor, S., Lascelles, K., Siddiqui, A., Hargrave, D., Ferner, R.E. 2017. Clinical presentation and prognostic indicators in 100 adults and children with neurofibromatosis 1 associated non-optic pathway brain gliomas. J Neurooncol.

Vormoor, B., Veal, G.J., Griffin, M.J., Boddy, A.V., Irving, J., Minto, L., Case, M., Banerji, U., Swales, K.E., Tall, J.R., Moore, A.S., Toguchi, M., Acton, G., Dyer, K., Schwab, C., Harrison, C.J., Grainger, J.D., Lancaster, D., Kearns, P., Hargrave, D., Vormoor, J. 2017. A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia. Pediatr Blood Cancer. 64(6).

Bluebond-Langner, M., Hargrave, D., Henderson, E.M., Langner, R. 2017. 'I have to live with the decisions I make': laying a foundation for decision making for children with life-limiting conditions and life-threatening illnesses. Arch Dis Child. 102(5) pp. 468-471.

Kinsler, V.A., O'Hare, P., Bulstrode, N., Calonje, J.E., Chong, W.K., Hargrave, D., Jacques, T., Lomas, D., Sebire, N.J., Slater, O. 2017. Melanoma in congenital melanocytic naevi. Br J Dermatol. 176(5) pp. 1131-1143.

Kinsler, V.A., O'Hare, P., Jacques, T., Hargrave, D., Slater, O. 2017. MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children. Br J Cancer. 116(8) pp. 990-993.

Veldhuijzen van Zanten, S.E., Baugh, J., Chaney, B., De Jongh, D., Sanchez Aliaga, E., Barkhof, F., Noltes, J., De Wolf, R., Van Dijk, J., Cannarozzo, A., Damen-Korbijn, C.M., Lieverst, J.A., Colditz, N., Hoffmann, M., Warmuth-Metz, M., Bison, B., Jones, D.T., Sturm, D., Gielen, G.H., Jones, C., Hulleman, E., Calmon, R., Castel, D., Varlet, P., Giraud, G., Slavc, I., Van Gool, S., Jacobs, S., Jadrijevic-Cvrlje, F., Sumerauer, D., Nysom, K., Pentikainen, V., Kivivuori, S.M., Leblond, P., Entz-Werle, N., von Bueren, A.O., Kattamis, A., Hargrave, D.R., et al. Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease. J Neurooncol. 132(2) pp. 255-266.

Baugh, J., Bartels, U., Leach, J., Jones, B., Chaney, B., Warren, K.E., Kirkendall, J., Doughman, R., Hawkins, C., Miles, L., Fuller, C., Hassall, T., Bouffet, E., Lane, A., Hargrave, D., Grill, J., Hoffman, L.M., Jones, C., Towbin, A., Savage, S.A., Monje, M., Li, X.N., Ziegler, D.S., Veldhuijzen van Zanten, S., Kramm, C.M., van Vuurden, D.G., Fouladi, M. 2017. The international diffuse intrinsic pontine glioma registry: an infrastructure to accelerate collaborative research for an orphan disease. J Neurooncol. 132(2) pp. 323-331. 

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