Dr Robert Chiesa

Consultant in Bone Marrow Transplants

Overview

Dr Robert Chiesa became a Consultant in Bone Marrow Transplantation (BMT) at Great Ormond Street Hospital (GOSH) in 2009.  

He trained at the Universita degli Sudi di Milano-Biocca, in Italy.  

Dr Chiesa’s areas of expertise include: novel conditioning regimens (Radio-immunotherapy), pharmacokinetics of chemotherapy agents (Treosulfan, Busulfan), umbilical cord blood transplantation, transplant in inborn errors of metabolism, anti-fungal prophylaxis and treatment in BMT. 

Languages Spoken:

  • Italian
  • English
  • Spanish

Credentials

  • Bone marrow transplantation in malignant and non malignant diseases 
  • Umbilical cord blood transplantation 
  • Novel conditioning regimens in BMT (Radio-immunotherapy) 
  • BMT in inborn errors of metabolism 
  • Pharmacokinetics of Busulfan and Treosulfan 
  • Anti-fungal treatment and prophylaxis in BMT
  • Novel conditioning regimens in BMT
  • PK of chemotherapy agents 
  • Immune reconstitution after BMT
  • Umbilical cord blood transplant 
  • Inborn errors of metabolism 
  • Anti-fungal prophylaxis and treatment in BMT 

Specialisation in paediatrics with honour (UK CCST equivalent) 

  • Novel conditioning regimens prior to BMT (radio-immunotherapy) 
  • Umbilical cord blood transplantation 
  • Immune reconstitution after BMT 
  • Drug pharmacokinetics prior to BMT (busulfan/treosulfan) 
  • BMT in inborn errors of metabolism 

News & Publications

Small, T.N., Qasim, W., Friedrich, W., Chiesa, R., et al. 2012. Alternative donor SCT for the treatment of MHC Class II deficiency. Bone Marrow Transplant. 

Zeilhofer, U., Ashworth, M., Amrolia, P., Rao, A., Chiesa, R., et al. 2012. Pulmonary hypertension following haematopoietic stem cell transplantation for primary haemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 

Hiwarkar, P., Gaspar, H.B., Gilmour, K., Jagani, M., Chiesa, R., et al. 2012. Impact of viral reactivations in the era of pre-emptive antiviral drug therapy following allogeneic haematopoietic SCT in paediatric recipients. Bone Marrow Transplant.

Worth, A.J., Nikolajeva, O., Chiesa, R., et al. 2013. Successful stem cell transplant with antibody-based conditioning for XIAP deficiency with refractory hemophagocytic lymphohistiocytosis. Blood. 121(24) pp. 4966-8.

Jackson, J., Titman, P., Butler, S., Bond, K., Rao, A., Veys, P., Chiesa, R., et al. 2013. Cognitive and psychosocial function post hematopoietic stem cell transplantation in children with hemophagocytic lymphohistiocytosis. Allergy Clin Immunol.132(4) pp. 889-895. 

Lindemans, C.A*., Chiesa, R*., Amrolia, P.J., et al. 2014. The impact of thymoglobulin prior to pediatric unrelated umbilical cord blood transplantation on immune-reconstitution and clinical outcome. Blood. 123 (1) pp. 126-32. *equal contribution. 

Hiwarkar, P., Gajdosova, E., Qasim, W., Worth, A., Breuer, J., Chiesa, R., et al. 2014. Frequent occurrence of Cytomegalovirus retinitis during immune-reconstitution warrants regular ophthalmic screening in high-risk pediatric allogeneic hematopoietic stem cell transplant recipients. Clinical Infectious Diseases. 

Hassan, A., Lee, P., Maggina, P., Xu, J.H., Moreira, D., Slatter, M., Nademi, Z., Worth, A., Adams, S., Jones, A., Cale, C., Allwood, Z., Rao, K., Chiesa, R., et al. 2014. Host natural killer immunity is a key indicator of permissiveness for donor cell engraftment in patients with severe combined immunodeficiency. J Allergy Clin Immunol. 

Nikolajeva, O., Mijovic, A., Hess, D., Tatam, E., Amrolia, P., Chiesa, R., et al. 2015. Single-donor granulocyte transfusions for improving the outcome of high-risk pediatric patients with known bacterial and fungal infections undergoing stem cell transplantation: a 10-year single-center experience. Bone Marrow Transplant. 

Rao, K., Adams, S., Qasim, W., Allwood, Z., Worth, A., Silva, J., Lucchini, G., Chiesa, R., et al. 2016. Effect of stem cell source on long-term chimerism and event-free survival in children with primary immunodeficiency disorders after fludarabine and melphalan conditioning regimen. J Allergy Clin Immunol.  

Admiraal, R., Chiesa, R., Lindemans, C.A., Nierkens, S., et al. 2016. Leukemia-free survival in myeloid leukemia, but not in lymphoid leukemia, is predicted by early CD4+ reconstitution following unrelated cord blood transplantation in children: a multicenter retrospective cohort analysis. Bone Marrow Transplant.   

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